The AzgA Purine Transporter of Aspergillus nidulans CHARACTERIZATION OF A PROTEIN BELONGING TO A NEW PHYLOGENETIC CLUSTER
作者： Gianna Cecchetto , Sotiris Amillis , George Diallinas , Claudio Scazzocchio , Christine Drevet
关键词: Biochemistry 、 Aspergillus nidulans 、 Gene 、 Phylogenetic tree 、 Membrane protein 、 Transcription (biology) 、 Genetics 、 Subfamily 、 Phylogenetics 、 Transposable element 、 Biology
摘要: The azgA gene of Aspergillus nidulans encodes a hypoxanthine-adenine-guanine transporter. It has been cloned by novel transposon methodology. null phenotype was defined number mutations, including large deletion. In mycelia, the is, like other genes purine catabolism, induced uric acid and repressed ammonium. Its transcription depends on pathway-specific UaY zinc binuclear cluster protein broad domain AreA GATA factor. AzgA is not closely related to any characterized membrane protein, but many close homologues unknown function are present in fungi, plants, prokaryotes metazoa. Two three data bases phylogeny presented this article places proteins family clearly separated (but perhaps phylogenetically related) from NAT that includes eukaryotic prokaryotic nucleobase transporters. Thus first member or subfamily proteins.
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