Strain diversity within Mycobacterium avium subspecies paratuberculosis--a review.

作者: Singh Sv , Singh Pk , Sohal Js , Singh Av

DOI:

关键词: VirulenceTypingGeneticsMicrobiologyFastidious organismMycobacterium avium subspecies paratuberculosisParatuberculosisRestriction fragment length polymorphismBiologyComparative genomicsHost adaptation

摘要: Mycobacterium avium subspecies paratuberculosis (MAP), is the etiological agent of Johne's disease (or paratuberculosis) in animals and has also been linked with Crohn's human beings. Extreme fastidious nature organism (MAP) hampered studies on diversity within organism. Studies based phenotypic properties like growth rate, pigmentation, lipid profile etc., are unable to provide complete information MAP nature. However, advent molecular assays (IS900 RFLP, PFGE, IS1311 PCR-REA, SSR typing, VNTR typing etc.) last 2 decades, progress made differentiate strains. isolates have classified into various types subtypes using these tools. Optimization led generation new about strains, subtypes, their comparative genomics, relative evolution, virulence etc. Knowledge strain important for better understanding sero-epidemiology, infection patho-biology, vaccine development planning control strategies. The present review provides available ho st adaptations, virulence,comparative genetic evolution differentiation.

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