Heart Rate Variability and Markers of Inflammation and Coagulation in Depressed Patients with Coronary Heart Disease

摘要: Abstract Background Depression is associated with an increased risk for cardiac morbidity and mortality in patients coronary heart disease (CHD). Cardiac autonomic nervous system (ANS) dysregulation, proinflammatory processes, procoagulant processes have been suggested as possible explanations. Methods Heart rate variability (HRV), indicator of regulation, markers inflammation [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] coagulation (fibrinogen) were assessed 44 depressed CHD. Results Moderate, negative correlations found between fibrinogen four measures HRV. IL-6 also negatively correlated one measure HRV (total power) was marginally related to two others (very low frequency power). Neither CRP nor TNF-α significantly any Conclusions The finding that are moderately suggests a link these factors CHD patients. relationship ANS function inflammatory coagulant should be investigated larger mechanistic studies depression mortality.