Depression and obstructive sleep apnea in patients with coronary heart disease.

作者: Robert M. Carney , William B. Howells , Kenneth E. Freedland , Stephen P. Duntley , Phyllis K. Stein

DOI: 10.1097/01.PSY.0000204632.91178.26

关键词: Coronary heart diseaseCardiologyInternal medicineAnesthesiaBreathingMedicineDepression (differential diagnoses)Obstructive sleep apneaHypopneaSleep medicineRisk factorApnea

摘要: Objective: Depression is a risk factor for cardiac events in patients with coronary heart disease (CHD). Obstructive sleep apnea/hypopnea syndrome (OSAHS) frequently comorbid depression and also events. Undetected OSAHS could help explain the increased associated depression. Methods: Medically stable CHD major (MD, n 53), minor (md, 36), or no (ND, 43) were evaluated 2 nights medicine laboratory. Results: The prevalence of did not differ across groups (MD 66%, md 69%, ND 77%; p .05). Patients MD had significantly greater frequency apneic episodes, longer duration apneas hyponeas, more oxygen desaturations per hour than those md, but there differences between episodes desaturations. However, males tended to have obstructive males, whereas females fewer females. Apnea was compared ND. There difference mean apnea groups. Conclusions: Although common depressed CHD, both men women higher men. Key words: depression, sleep-disordered breathing, disease. disease; depression; nondepressed; syndrome; AHI index; LVEF left ventricular ejection fraction; BDI Beck Inventory; BMI body mass DISH Interview Structured Hamilton.

参考文章(31)
John W. Winkelman, Lynette James, Serotonergic antidepressants are associated with REM sleep without atonia. Sleep. ,vol. 27, pp. 317- 321 ,(2004) , 10.1093/SLEEP/27.2.317
Kate E Hamilton, Keith S Dobson, Cognitive therapy of depression: pretreatment patient predictors of outcome. Clinical Psychology Review. ,vol. 22, pp. 875- 893 ,(2002) , 10.1016/S0272-7358(02)00106-X
Larry E. Beutler, J. Catesby Ware, Ismet Karacan, John I. Thornby, Differentiating psychological characteristics of patients with sleep apnea and narcolepsy. Sleep. ,vol. 4, pp. 39- 47 ,(1981) , 10.1093/SLEEP/4.1.39
Sewitch De, Coble Pa, Kupfer Dj, Taska Ls, Reynolds Cf rd, McEachran Ab, Depressive psychopathology in male sleep apneics. The Journal of Clinical Psychiatry. ,vol. 45, pp. 287- ,(1984)
H Kreuzer, S Andreas, G S Werner, R Schulz, Prevalence of obstructive sleep apnoea in patients with coronary artery disease. Coronary Artery Disease. ,vol. 7, pp. 541- 545 ,(1996)
Robert M. Carney, Kenneth E. Freedland, Depression and Heart Disease Biology of Depression. pp. 617- 631 ,(2005) , 10.1002/9783527619672.CH24
Terry Young, Linda Evans, Laurel Finn, Mari Palta, Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. Sleep. ,vol. 20, pp. 705- 706 ,(1997) , 10.1093/SLEEP/20.9.705
Barry S. Fogel, Carol C. Carlisle, Richard P. Millman, Mary E. McNamara, Depression as a manifestation of obstructive sleep apnea: reversal with nasal continuous positive airway pressure The Journal of Clinical Psychiatry. ,vol. 50, pp. 348- 351 ,(1989)
L. L. Kupper, K. E. Muller, D. G. Kleinbaum, Applied Regression Analysis and Other Multivariable Methods ,(1978)
Stanley Lemeshow, David W. Hosmer, Applied Logistic Regression ,(1989)