Neonatal temperament and neuromotor differences are predictive of adolescent alcohol intake in rhesus monkeys (Macaca mulatta).

摘要: Identifying predictors of teenage alcohol use disorder (AUDs) is a major health initiative, with studies suggesting that there are distinct personality-related traits underlie patterns intake. As temperament biologically based, identifiable early in life, and stable across time, it considered the foundation personality. such, we hypothesized neonatal would predict anxiety-mediated adolescent consumption. To test this, N = 145 rhesus macaque (Macaca mulatta) infants (14 days age), reared nursery (n = 82) or control condition their mothers (n = 63) were assessed widely used standardized nonhuman primate testing battery, Infant Behavioral Assessment Scale (IBAS), modeled after Brazelton Neonatal Scale, evaluating visual orienting, temperament, motor maturity and, more recently, sensory sensitivity. adolescents (3-4 years these same subjects allowed unfettered access to sweetened-alcohol solution for 1 hr/day, 4 days/week, over 5-7 weeks. Subjects self-administer while housed alone (n = 70) socially home cage (n = 55). Linear regressions showed intake was predicted by orienting ability (β = -.35; p = .01), state (β = -.19; p = .04), (β = -.24; p = .01). Poor (ease consolability), associated higher monkeys. These findings suggest predictive extent results generalize humans, they provide evidence early-life neurodevelopment may be important risk factors AUDs IBAS as an assessment tool identifying such risk.