Current topical and systemic approaches to treatment of rosacea

摘要: Rosacea is a common, often overlooked, chronic facial dermatosis characterized by intermittent periods of exacerbation and remission. Clinical subtypes grading the disease have been defined in literature. On basis genetic predisposition, there are several intrinsic extrinsic factors possibly correlating with phenotypic expression disease. Although rosacea cannot be cured, recommended treatment strategies appropriate to control corresponding symptoms/signs. In addition adequate skin care, these include topical systemic medications particularly suitable for papulopustular subtype moderate severe intensity. The most commonly used established therapeutic regimens metronidazole azelaic acid as well oral doxycycline. Conventionally, 100-200 mg per day used. Today also controlled release formulation available, delivering 40 using non-antibiotic, anti-inflammatory activities drug. Anti-inflammatory dose doxycycline particular allows safe effective short- long-term therapy rosacea. Topical appear short-term use. There indications that combined could synergy effects. Further interesting options low-dose minocycline isotretinoin; however, too little data available regard effectiveness, safety, optimal dosage length draw final conclusions.