Influence of endothelium on Mg2+-induced relaxation in noradrenaline-contracted aorta from DOCA-salt hypertensive rat

摘要: The aim of this study was to examine the influence vascular endothelium on relaxation induced by increased extracellular Mg2+ concentrations isolated and noradrenaline-precontracted aorta from deoxycorticosterone acetate-salt (DOCA-salt) hypertensive normotensive rats. In Mg2+-free physiologic salt solution (PSS), addition (0.1–6.0 mM) caused concentration-dependent with intact or disrupted endothelium. Mg2+-induced in aorta, however, less DOCA-salt rats than When disrupted, depressed both same observations were made presence N-nitro-L-arginine methyl ester (L-NAME), an inhibitor endothelium-derived relaxing factor nitric oxide (EDRF/NO) biosynthesis. following contraction noradrenaline significantly treated L-NAME Indomethacin did not affect whereas indomethacin it It is concluded that (1) can be mediated endothelium-dependent mechanisms implicating EDRF/NO; (2) EDRF/NO more pronounced impaired rats; (3) seems masked vasoconstrictor prostaglandin release (4) these differences between could related endothelial function