Implant-forming polymeric 19F MRI-tracer with tunable dissolution.

摘要: Abstract Magnetic resonance imaging (MRI) using 19F-based tracers has emerged as a promising multi-purpose noninvasive diagnostic tool and its application requires the use of various for intended purpose. In this study, we report series double-stimuli-responsive polymers injectable implants, which were designed to form implants under physiological conditions, subsequently dissolve with different dissolution rates (t1/2 ranges from 30 more than 250 days). Our contain high concentration fluorine atoms, providing remarkable signal detectability, both hydrophilic monomer pH-responsive that alter biodistribution properties implant. The implant location observed 19F MRI, allows anatomic extent be monitored. kinetics biocompatibility these materials thoroughly analyzed. No sign toxicity in vitro or vivo pathology was observed, even chronic administration. clinical applicability our further confirmed via rat model by employing an instrument currently used human medicine.