Transgenic and Genetic Animal Models

摘要: Development of approaches to manipulate the murine genome has greatly expanded our capability perform mechanistic studies examine molecular underpinnings endocrine-based behaviors. These have spawned novel models human disease and instigated production animals where processes can be directly probed in brain. It is anticipated that use genetic methodology will continue grow revolutionize understanding precise interplay between genes their environment regulating diverse This chapter focuses on techniques used construct various genetically based animal including transgenic mice, knockout knockin animals, for temporal spatial pattern a targeted change. Specific examples are included demonstrate utility these answer questions relevant basis hormonal control behavior.