Differential Survival of Naive CD4 and CD8 T Cells

摘要: In this paper we compare survival characteristics of transgenic and polyclonal CD4 CD8 T cells. Transgenic cells have an intrinsically lower capacity for survival, reflected in their gradual disappearance thymectomized hosts, increased sensitivity to apoptosis vitro, fewer divisions during homeostatic proliferation upon transfer into syngeneic lymphopenic hosts compared with Homeostatic proliferation, however, does not generally result phenotypic conversion activation markers unless cognate or cross-reactive Ag is present. from the A18 TCR strain normally selected lineage are fragile as cells, yet display typical robust pattern when diverted a CD4-deficient host. Polyclonal also show distinctive patterns emphasizing that signals relayed differently two lymphocyte subpopulations. However, expression levels Bcl-2 either naive similar, excluding role molecule key factor differential vs