Universal screening versus selective case-based screening for thyroid disorders in pregnancy.

摘要: Thyroid dysfunction in pregnancy is associated with significant maternal, fetal, and neonatal complications. Early treatment of thyroid disorders can effectively reduce the risk such The results different clinical trials have demonstrated that screening pregnant women for dysfunctions cost-effective should be encouraged. However, there no consensus over advantages universal versus case-finding during pregnancy. A systematic review was performed by searching PubMed, Scopus, Web Science databases studies having been carried out to make a comparison between methods terms loss rate. main search criteria were related function, pregnancy, adverse outcomes. All articles English language are included. We analyzed random effect method due between-study heterogeneity. Among 241 found using terms, 40 included which 10 considered as acceptable relevant. Five showed missed 30 55 % dysfunction. 4 detection may lead less miscarriage 2 focus on hypothyroidism would cost-effective. minimize maternal fetal outcomes Meta-analysis confirmed case-based miss up 49 This provides further support argument favor In order shed more light comprehensive randomized controlled larger cohorts required.