Adolescence and Scoliosis: Deciphering the Complex Biology of Puberty and Scoliosis

摘要: Adolescent idiopathic scoliosis (AIS) is the most common paediatric spinal disorder, affecting 2–5.2% of population. Individuals with AIS have, for a long time, been known to exhibit differences in weight, height, body mass index (BMI), pubertal progression and levels circulating hormones, suggesting that may arise due metabolism-endocrine-gene interactions. Here, we present an overview biological changes occur during puberty, relation developing spine, along pathways involved, emphasis on those linked through recent human genetic studies.