Maintenance of eupnea and gasping following alterations in potassium ion concentration of perfusates of in situ rat preparation.

摘要: Levels of extracellular potassium ion, above those in vivo, are required for the generation rhythmic activities vitro preparations. Our purpose was to define whether hyperkalemia perfusate an situ preparation likewise necessary expression eupnea and gasping. Studies were performed using juvenile rat, which activity phrenic nerve recorded as index respiratory rhythm. Eupnea gasping impervious modifications ion perfusate. maintained uninterrupted more than 60 min total concentration hypokalemic (2.75 mM), normokalemic (4.0 or hyperkalemic (6.25 7.75 mM). Gasping, with identical characteristics, elicited at any ion. We conclude that both unaffected by modest changes rat is maintained. These results add further support conclusion represents a model accurately reproduces mechanisms rhythm vivo.