Risk factors for and expression of immune and inflammatory factors in atopic dermatitis in Chinese population: A birth cohort study.

摘要: Abstract Objective To explore the risk factors for atopic dermatitis (AD) and disclose relationship between immune inflammatory (Immunoglobulin E (IgE), interleukin (IL)-4, IL-18) prevalence of AD in a Chinese population. Methods evaluate infant AD, total 921 mother-newborn pairs were recruited through questionnaire survey conducted during 2009–2011. Venous blood was collected from mothers birth hospitalization umbilical cord delivery. Thirty-five infants with paired their served as patient group. non-AD selected randomly used control Enzyme-linked immunosorbent assay (ELISA) performed to detect levels IgE, IL-4, IL-18. The IL-18 analyzed. allergy assessed IgE positive cases. Results Family income, parental history atopy, age menarche, performing housing renovation before pregnancy, instance virus infection calcium supplementation pregnancy potential determining incidence rate AD. Compared group, group showed higher IL-4 both maternal serum ( P Conclusion well level are related occurrence childhood Potential include family infection, pregnancy.