Seguimiento del estado nutricional y calidad de vida de pacientes que inician tratamiento con inhibidores tirosin kinasa

摘要: Background and objective: The consumption of oral antineoplastics -and more particularly tyrosine-kinase inhibitors (TKI)- has increased in recent years. These therapies show a better tolerance but still, the nutritional alterations related to their daily chronic clinical use are under investigation. This study assesses effects TKI on intake, status micronutrients as well patients quality life. Methods: A prospective longitudinal was conducted including adult having started some treatment from July 2012 June 2013, 6 month follow-up period established. Demographic pharmacotherapeutic, biochemical variables were collected also EORTC-QLQ30 questionnaire at baseline, first, third sixth treatment. Results: 31 included study. percentage weight loss baseline statistically matched results patient-generated Global Subjective Assessment. Appetite decreased after one treatment, so did calorie consumption; 62.1% lost weight, 55.5% 70.6% month. 6-17% suffered malnutrition degree during decrease calcium, phosphate magnesium plasma levels detected. emotional scale with lowest score EORTC QLQ-30, fatigue lack appetite most common symptoms progressively increasing those nausea, vomits diarrhea. Discussion: Patients treated not relevant malnutrition. Considering results, it is important take into account baseline; control calcium advise counsel patient GI (nausea, diarrhea) emotionally reinforce patient.