Metallothionein expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patient survival.
作者： Stamatios Theocharis , Jerzy Klijanienko , Constantinos Giaginis , Jose Rodriguez , Thomas Jouffroy
DOI: 10.1111/J.1365-2559.2011.03947.X
关键词: Mobile tongue 、 Lymph node 、 Metallothionein 、 Cancer 、 Staining 、 Clinical significance 、 Pathology 、 Immunohistochemistry 、 Apoptosis 、 Biology
摘要: Theocharis S, Klijanienko J, Giaginis C, Rodriguez Jouffroy T, Girod A, Point D, Tsourouflis G & Sastre-Garau X (2011) Histopathology59, 514–525 Metallothionein expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patient survival Aims: Metallothionein (MT) has been implicated several aspects of cancer pathobiology, such as differentiation, proliferation, apoptosis invasion. The aim the present study was to evaluate clinical significance MT carcinoma (SCC). Methods results: protein assessed immunohistochemically on 49 SCC specimens, analysed relation characteristics, overall disease-free survival. All examined cases showed positivity tumour cells; however, neither overexpression nor staining intensity significantly associated parameters. cellular distribution histopathological grade differentiation depth invasion (P = 0.0188 P = 0.0484, respectively). identified a significant predictor survival at both univariate (P = 0.0377) multivariate (P = 0.0472) levels. Twenty-seven (55.10%) epithelium adjacent tumour, being correlated (P = 0.0281), vascular (P = 0.0194), existence lymph node metastases (P = 0.0194). Conclusions: may be development progression could considered useful marker for management prognosis.
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