Impact of comorbidity on outcome of young patients with head and neck squamous cell carcinoma.

摘要: Background. Comorbid conditions have a significant impact on the actuarial survival of patients with head and neck cancer. However, no studies evaluated comorbidity tumor- treatment-specific outcomes. This study was performed to evaluate comorbidity, graded by Kaplan-Feinstein index (KFI) incidence severity complications, disease-free interval, tumor-specific in undergoing curative treatment for Methods. A multi-institutional, retrospective cohort 70 45 years age under squamous cell carcinoma (SCC) presenting over an 11-year period studied. Results. Advanced (KFI grade 2 or 3) present 21 (30%). Patients advanced did not differ from low-level grades 0 1) sex distribution, race, presence human immunodeficiency virus (HIV) infection, tobacco use, location primary lesion, stage at presentation, pathologic differentiation tumor, type initial treatment. The overall treatment-associated complications similar between groups (57% versus 49%; p > 0.05), but higher proportion developed high-grade (24% 6%; =.04). median interval (11.1 months 21.6 months; =.045) (13.7 57.6 =.03) poorer comorbidity. effects remained even after adjusting confounding HIV status tumor (p =.05). Conclusions. comorbid has Although is associated increase rate tend be more severe this population. More importantly, detrimental effect cancer, independent other factors. suggests that may behavior, presumably altering host's response Accordingly, predictive reliable, current staging system cancer should include description patient's