Prognostic Models in Head and Neck Oncology: Predictors and dynamics

摘要: textabstractHead and neck malignancies originating from the mucosal lining of upper aerodigestive tract (head squamous cell carcinoma’s: HNSCC’s) salivary glands make up nearly 5% total number malignant tumours in Netherlands. Variation of incidence trends between sites exist1, general HNSCC’s is 17/100,000; the gland 0.7/100,000 (Netherlands Cancer Registry). In this thesis we discuss prognostics both types cancer, although focus on HNSCC’s. Once diagnosed with head prognosis (likely outcome of the disease) plays an enormous role choosing treatment options informing patients. Generally, survival rates for patients vary depending on type stage (extent) cancer involved. The fi ve-years rate (the percentage patients who survive at least ve years after detected) HNSCC around 50%. For those gure highly dependent tumour and diff ers 30% to 100%. time diagnosis cancer is taken into account choice treatment. When it comes patients about their prognosis, physicians also incorporate events such as staying free cancer or occurrence a non related health event (eg. myocardial infarction) during follow up. methods determination way changes over time and which should be discussed are central themes of thesis. This introduction aims explore concept fallibility of prognostic factors, statistical used when working prognostic factors and process decision-making. Finally, will state the central hypotheses