Smoking tobacco, oral snuff, and alcohol in the etiology of squamous cell carcinoma of the head and neck: a population-based case-referent study in Sweden.

摘要: BACKGROUND This case-referent study was conducted to elucidate the role of selected exogenous agents in etiology head and neck cancer. The factors studied were tobacco smoking, alcohol intake, use moist oral snuff, dietary factors, occupational exposures, hygiene. In this first report, authors discuss impact consumption. METHODS The base approximately 2 million person-years at risk consisted Swedish males age 40-79 years living geographic regions during 1988-1990. A total 605 cases identified base, 756 controls by stratified random sampling from population registries covering base. RESULTS Among those who smokers time study, relative cancer 6.5% (95% confidence interval, 4.4-9.5%). After cessation gradually declined, no excess found after 20 years. associated with consumption 50 grams or more per day versus less than 10 5.5% 3.1-9.6%). An almost multiplicative effect for smoking consumption. CONCLUSIONS Tobacco intake had a strong interactive on squamous cell carcinoma neck. Moderate (10-19 day) little among nonsmokers. No increased snuff. Cancer 1998;82:1367-75. © 1998 American Society.