Real‐Time In Situ Powder X‐ray Diffraction Monitoring of Mechanochemical Synthesis of Pharmaceutical Cocrystals
作者： Ivan Halasz , Andreas Puškarić , Simon A. J. Kimber , Patrick J. Beldon , Ana M. Belenguer
关键词: Grinding 、 Nanotechnology 、 Mechanochemistry 、 X-ray crystallography 、 Cocrystal 、 Materials science 、 Reaction mechanism 、 Particle 、 In situ
摘要: Looking in: The penetrating power of high-energy X-rays provides a means to monitor in situ and in real time the course ball-milling reactions organic pharmaceutical solids by detecting crystalline phases assessing evolution their particle sizes. Upon switching from neat grinding liquid-assisted grinding, cocrystal formation is enabled or tremendously accelerated, while reaction mechanism alters its course.
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