Erythromycin lacks colon prokinetic effect in children with functional gastrointestinal disorders: a retrospective study
作者： Narayanan Venkatasubramani , Colin D Rudolph , Manu R Sood
关键词: Functional constipation 、 Gastroenterology 、 Migrating motor complex 、 Erythromycin Lactobionate 、 Constipation 、 Medicine 、 Erythromycin 、 Motilin 、 Motilin receptor 、 Gastrointestinal agent 、 Internal medicine
摘要: Background Motilin, a peptide hormone has direct excitatory effect on circular smooth muscle strips derived from the human colon. Reduced plasma motilin concentration been reported in adults with chronic constipation. Erythromycin, non-peptide receptor agonist, induces phase 3 of migrating motor complex (MMC) antro-duodenum and also reduces oro-cecal transit time. A pediatric study an improvement clinical symptoms constipation following erythromycin administration, but colon motility children not formally evaluated. We used manometry to intravenous lactobionate at 1 mg/kg motiltiy ten children.
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