Resistivity probing of multi-layered tissue phantoms using microelectrodes

作者: Pontus Linderholm , Arnaud Bertsch , Philippe Renaud

DOI: 10.1088/0967-3334/25/3/005

关键词: MethacrylatePolymerMicroelectrodeBiomedical engineeringElectrical impedance tomographyMaterials scienceElectrodeSelf-healing hydrogelsElectrical resistivity and conductivityIonic strength

摘要: We present the use of an array rectangular microelectrodes to discriminate between different resistivities in a thin, layered sample. Each electrode was 8 mm long and 200 nm thick. The widths ranged from 20 500 µm. electrodes were designed such that all pairs consecutive had same relative geometry, therefore identical cell constants. A hydrogel-based tissue phantom, made by photopolymerization 2-hydroxyethyl methacrylate (HEMA), developed. By changing hydrogel composition ionic strength storage medium, resistivity hydrogels could be tuned 100 Ωm kΩm. Using bipolar measurements, phantoms characterized frequency range Hz 30 MHz. distribution three-layered structure composed 120 µm sheets calculated shown agree within 7% bulk measurements. Potential clinical applications for this technique include probing epithelial skin cancer screening.

参考文章(41)
J. R. Meakin, D. W. L. Hukins, R. M. Aspden, C. T. Imrie, Rheological properties of poly(2-hydroxyethyl methacrylate) (pHEMA) as a function of water content and deformation frequency. Journal of Materials Science: Materials in Medicine. ,vol. 14, pp. 783- 787 ,(2003) , 10.1023/A:1025088405674
J. Ricka, Toyoichi Tanaka, Swelling of Ionic Gels : Quantitative Performance of the Donnan Theory Macromolecules. ,vol. 17, pp. 2916- 2921 ,(1984) , 10.1021/MA00142A081
B H Brown, D C Barber, A D Seagar, Applied potential tomography: possible clinical applications Clinical Physics and Physiological Measurement. ,vol. 6, pp. 109- 121 ,(1985) , 10.1088/0143-0815/6/2/002
W. Hilberg, From Approximations to Exact Relations for Characteristic Impedances IEEE Transactions on Microwave Theory and Techniques. ,vol. 17, pp. 259- 265 ,(1969) , 10.1109/TMTT.1969.1126946
H M Powell, D C Barber, I L Freeston, Impedance imaging using linear electrode arrays. Clinical Physics and Physiological Measurement. ,vol. 8, pp. 109- 118 ,(1987) , 10.1088/0143-0815/8/4A/015
Matthew J. Lesho, Norman F. Sheppard, A method for studying swelling kinetics based on measurement of electrical conductivity Polymer Gels and Networks. ,vol. 5, pp. 503- 523 ,(1998) , 10.1016/S0966-7822(97)00024-5
Trevor York, Liling Sun, Chris Gregory, John Hatfield, Silicon-based miniature sensor for electrical tomography Sensors and Actuators A-physical. ,vol. 110, pp. 213- 218 ,(2004) , 10.1016/J.SNA.2003.08.012
Paul C. Nicolson, Jürgen Vogt, Soft contact lens polymers: an evolution Biomaterials. ,vol. 22, pp. 3273- 3283 ,(2001) , 10.1016/S0142-9612(01)00165-X
P. Jacobs, A. Varlan, W. Sansen, Design optimisation of planar electrolytic conductivity sensors Medical & Biological Engineering & Computing. ,vol. 33, pp. 802- 810 ,(1995) , 10.1007/BF02523012
Y Zou, Z Guo, A review of electrical impedance techniques for breast cancer detection Medical Engineering & Physics. ,vol. 25, pp. 79- 90 ,(2003) , 10.1016/S1350-4533(02)00194-7