Discovery of potential negative allosteric modulators of mGluR5 from natural products using pharmacophore modeling, molecular docking, and molecular dynamics simulation studies
作者： Ludi Jiang , Yong Li , Liansheng Qiao , Xi Chen , Yusu He
关键词: Molecular dynamics 、 Chemistry 、 Stereochemistry 、 Allosteric regulation 、 SUPERFAMILY 、 Computational biology 、 Metabotropic glutamate receptor 5 、 Pharmacophore
摘要: mGluR5, which belongs to the G-protein-coupled receptor superfamily, is believed be associated with many human diseases, such as a wide range of neurological disorders, gastroesophageal reflux d...
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