The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes.
作者： Rebecca Feltham , John Silke
DOI: 10.1038/CDD.2017.67
关键词: Ubiquitin 、 Caspase 8 、 Biology 、 Cell biology 、 RIPK1 、 FADD 、 Programmed cell death 、 Cell fate determination 、 Regulation of gene expression 、 NFKB1
摘要: … of RIPK1, potentially by delaying or limiting the recruitment of RIPK1 to a FADD/caspase-8 … This is demonstrated by the fact that mutation of a critical lysine in RIPK1, K377, to arginine …
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