Dry amorphisation of mangiferin, a poorly water-soluble compound, using mesoporous silica.
作者： Adrienn Baán , Peter Adriaensens , Joris Lammens , René Delgado Hernandez , Wim Vanden Berghe
DOI: 10.1016/J.EJPB.2019.05.026
关键词: Dissolution 、 Amorphous solid 、 Fourier transform infrared spectroscopy 、 Particle size 、 Chemical engineering 、 Ball mill 、 Mesoporous silica 、 Mangiferin 、 Solubility 、 Materials science
摘要: Abstract Mangiferin, a poorly water soluble compound, was processed via dry amorphisation technique (ball milling) in combination with mesoporous silica to enhance the solubility of mangiferin. The amorphous samples were prepared by mixing 1:1 (w/w) Syloid® XDP 3050 silica-mangiferin mixtures using planetary mono mill at different milling speeds and times according 32 full factorial experimental design. characterized for dissolution profile, particle size distribution laser diffraction analyzer, thermal characteristics DSC, crystalline XRD molecular interactions FTIR ss-NMR. tested stability stress conditions (40 °C/75%RH) up 6 months open closed containers. To improve samples, 1:1:2 mangiferin-polymer (Soluplus or HPMC)-silica also analyzed. Amorphisation mangiferin is possible ball short amount time. rate improved energy input process. high resulted showed better 3 months. Solubility these increased from 0.32 0.50 mg/ml decreased 35.5 µm around 7 µm. spectral analysis suggest presence between material compound. addition polymer, even though lower.
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