Mesoporous Silica Drug Delivery Systems

摘要: As solid dispersions have become an accepted method to improve the amorphous stability and increase solubility of drug substances, mesoporous silicas attractive option create dispersions, topic significant research into its efficacy safety as a functional excipient for enhanced delivery. The use dissolution profile has been investigated over four decades many materials techniques developed. This review is basic overview background, theory, materials, methods used by growing number researchers. It focused on macroparticulate delivery, particularly silica-based oral dosage forms. draws large field available, relevant that published. attempts provide general references deeper investigation. provides brief history description identifies applications when in discusses theoretical basis mechanisms release from silicas, describes both solvent-based solvent-free loading, effects different physical chemical properties they relate loading dissolution, possible characterize evaluate dispersion systems created. meant guide current status starting point further investigation interested scientists.