Mesoporous silica based macromolecules for dissolution enhancement of Irbesartan drug using pre-adjusted pH method
作者： Mai Khanfar , Mohammad M. Fares , Mu’taz Sheikh Salem , Amjad M. Qandil
DOI: 10.1016/J.MICROMESO.2013.02.007
关键词: Macromolecule 、 Dissolution testing 、 Dissolution 、 Chemical engineering 、 Mesoporous silica 、 Chemistry 、 Fourier transform infrared spectroscopy 、 Irbesartan 、 Crystallinity 、 Drug 、 Inorganic chemistry
摘要: Abstract Dissolution enhancement of poorly water-soluble Irbesartan drug through formation Irbesartan-silica based microcapsules has been investigated. The were fully characterized using FTIR, DSC, XRD and SEM techniques. Pre-adjusted pH method utilized to form efficient Irbesartan–silica capable enhance dissolution rate at the challenging 5.5 value. formed showed large increase as Neusilin feed ratio pre-adjusted increased. maximum was achieved via salt 7.4 1:3 microcapsules. successful owed destruction crystallinity accompanied with elevated pre-adjustment leading apparent dissolution.
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