Investigating the Effects of Loading Factors on the In Vitro Pharmaceutical Performance of Mesoporous Materials as Drug Carriers for Ibuprofen
作者： Junmin Lai , Wu Lin , Peter Scholes , Mingzhong Li
DOI: 10.3390/MA10020150
关键词:
摘要: The aim of the study was to investigate effects loading factors, i.e., initial drug concentration and ratio carriers, on in vitro pharmaceutical performance drug-loaded mesoporous systems. Ibuprofen (IBU) used as a model drug, two non-ordered materials commercial silica Syloid® 244FP (S244FP) Neusilin® US2 (NS2) were selected study. IBU-loaded samples prepared by solvent immersion method with rotary evaporation drying technique characterized polarized light microscopy (PLM), Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction (XRPD) differential scanning calorimetry (DSC). Dissolution experiments performed simulated gastric media at 37 °C under non-sink conditions. IBU solution determined HPLC. showed that dissolution rate can be improved significantly using S224FP carriers due conversion crystalline into amorphous form. Both factors affected kinetics. Due molecular interaction between NS2 had little release kinetics incomplete desorption recovery insignificant enhancement. Care extensive evaluation must therefore taken when are chosen carrier delivery
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