A mild deuterium exchange reaction of free carboxylic acids by photochemical decarboxylation.
作者： Tatsuya Itou , Yasuharu Yoshimi , Keisuke Nishikawa , Toshio Morita , Yutaka Okada
DOI: 10.1039/C0CC01464H
关键词: Decarboxylation 、 Nuclear magnetic resonance spectroscopy 、 Deuterium 、 Thiol 、 Chemistry 、 Barton decarboxylation 、 Hydrogen–deuterium exchange 、 Regioselectivity 、 Catalysis 、 Organic chemistry 、 Photochemistry
摘要: Deuterium exchange of a carboxy group was achieved by photochemical decarboxylation free carboxylic acids in the presence thiol and small amount D2O, deuterated product with excellent deuterium content obtained; this reaction is practical means synthesizing regioselective deuterium-labelled compounds under mild conditions.
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