Clinical Proteomics for Precision Medicine: The Bladder Cancer Case.

摘要: Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics approaches. Proteomics attract high interest, as proteins reflect a “real-time” dynamic phenotype. Focusing proteomics applications for personalized medicine, literature search was conducted to cover: a) disease prevention, b) monitoring/ prediction treatment response, c) stratification guide intervention and d) identification drug targets. review indicates potential also highlighting multiple challenges be prior actual implementation. In oncology, particularly bladder cancer, precision appears especially promising. heterogeneity recurrence rates together with limited options, suggests that earlier more efficient intervention, continuous monitoring development alternative therapies could accomplished applying proteomics-guided This notion is backed studies presenting biomarkers are value in prognosis, recent demonstrating promising Herein, we aim present an approach whereby combining knowledge targets cancer serve basis towards proteomics- guided management.