Electronic control of H + current in a bioprotonic device with Gramicidin A and Alamethicin

摘要: In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions small molecules across cell membranes. A bioelectronic device with control ionic flow a supported lipid bilayer (SLB) should therefore be ideal for interfacing systems. Here, we demonstrate biotic–abiotic bioprotonic Pd contacts regulates proton (H+) an SLB incorporating the Gramicidin (gA) Alamethicin (ALM). We model characteristics using Goldman–Hodgkin–Katz (GHK) solution to Nernst–Planck equation transport membrane. derive permeability integrating gA ALM pH as function applied voltage permeability. This work opens door more complex H+ at contact interface produce responsive devices increased functionality. Conventional electronics use electrons charge carriers whereas systems ions, confounding integration biology. Here authors show voltage-regulated protons channel voltage-gated Alamethicin.