Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: activation of PPAR-alpha.

作者: T HSUNWEIHUANG , G PENG , G QIANLI , J YAMAHARA , B ROUFOGALIS

DOI: 10.1016/J.TAAP.2005.05.003

关键词: Lipoprotein lipaseHyperlipidemiaSteatosisPeroxisome proliferator-activated receptor alphaSalacia oblongaBiologyInternal medicinePostprandialEndocrinologyTriglycerideFatty liver

摘要: … SO extract improves postprandial hyperlipidemia and hepatic … and enzyme activity in THP-1 differentiated macrophages; … for improvement of postprandial hyperlipidemia and hepatic …

参考文章(50)
James P. KEHRER, Shyam S. BISWAL, Eunhye LA, Philippe THUILLIER, Kaushik DATTA, Susan M. FISCHER, John P. VANDEN HEUVEL, Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886 Biochemical Journal. ,vol. 356, pp. 899- 906 ,(2001) , 10.1042/0264-6021:3560899
Gordon A. Francis, Jean-Sébastien Annicotte, Johan Auwerx, PPAR-α effects on the heart and other vascular tissues American Journal of Physiology-heart and Circulatory Physiology. ,vol. 285, ,(2003) , 10.1152/AJPHEART.01118.2002
Anne Minnich, Nian Tian, Lisa Byan, Glenda Bilder, A potent PPARα agonist stimulates mitochondrial fatty acid β-oxidation in liver and skeletal muscle American Journal of Physiology-endocrinology and Metabolism. ,vol. 280, ,(2001) , 10.1152/AJPENDO.2001.280.2.E270
S. Bonilla, A. Redonnet, C. Noël-Suberville, R. Groubet, V. Pallet, P. Higueret, Effect of a pharmacological activation of PPAR on the expression of RAR and TR in rat liver Journal of Physiology and Biochemistry. ,vol. 57, pp. 1- 8 ,(2001) , 10.1007/BF03179807
Y.-T. Zhou, M. Shimabukuro, M.-Y. Wang, Y. Lee, M. Higa, J. L. Milburn, C. B. Newgard, R. H. Unger, Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 8898- 8903 ,(1998) , 10.1073/PNAS.95.15.8898
Sander Kersten, Béatrice Desvergne, Walter Wahli, Roles of PPARs in health and disease Nature. ,vol. 405, pp. 421- 424 ,(2000) , 10.1038/35013000
Gary D. Lopaschuk, Metabolic abnormalities in the diabetic heart. Heart Failure Reviews. ,vol. 7, pp. 149- 159 ,(2002) , 10.1023/A:1015328625394
Shivakumar Chitturi, Geoffrey C. Farrell, Etiopathogenesis of Nonalcoholic Steatohepatitis Seminars in Liver Disease. ,vol. 21, pp. 027- 042 ,(2001) , 10.1055/S-2001-12927
Masayuki YOSHIKAWA, Norihisa NISHIDA, Hiroshi SHIMODA, Miki TAKADA, Yuzo KAWAHARA, Hisashi MATSUDA, Salacia属植物のポリフェノール成分:α-グルコシダーゼ及びアルドースレダクターゼ阻害活性成分,Mangiferin,の定量分析 Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan. ,vol. 121, pp. 371- 378 ,(2001) , 10.1248/YAKUSHI.121.371
D. Festi, A. Colecchia, T. Sacco, M. Bondi, E. Roda, G. Marchesini, Hepatic steatosis in obese patients: clinical aspects and prognostic significance Obesity Reviews. ,vol. 5, pp. 27- 42 ,(2004) , 10.1111/J.1467-789X.2004.00126.X