Prognostic Markers in Rheumatoid Arthritis and Classification of Antirheumatic Therapies

作者: Ernest H.S. Choy , David L. Scott

DOI: 10.2165/00003495-199500501-00004

关键词: Rheumatoid arthritisOncologyClinical significanceRheumatoid factorMagnetic resonance imagingHigh morbidityPharmacotherapyInternal medicineMedicineOsteoporosisPathologySevere disease

摘要: Rheumatoid arthritis is characterised by a generally poor outcome and high morbidity, has variable course. Identifying those patients most likely to have prognosis of key clinical significance. Disease can be predicted from variety prognostic markers. Some these are simple demographic features the patients, include age, disease duration, gender. Others more specific rheumatoid arthritis, including presence early erosive changes on plain radiographs, factor titres, levels C-reactive protein, scores for activity. Although no single marker adequate specificity or sensitivity form basis decisions, several predictive severe disease. Thus, with damage who seropositive protein outcome. New markers imaging techniques become tools future. These genetic markers, combination magnetic resonance dual energy x-ray absorption scans localised osteoporosis.

参考文章(68)
F Wolfe, M A Cathey, The assessment and prediction of functional disability in rheumatoid arthritis. The Journal of Rheumatology. ,vol. 18, pp. 1298- 1306 ,(1991)
D. Van Schaardenburg, J. M. W. Hazes, A. De Boer, K. A. E. Meijers, A. H. Zwinderman, F. C. Breedveld, Outcome of rheumatoid arthritis in relation to age and rheumatoid factor at diagnosis. The Journal of Rheumatology. ,vol. 20, pp. 45- 52 ,(1993)
J F Fries, P W Spitz, D Y Young, The dimensions of health outcomes: the health assessment questionnaire, disability and pain scales. The Journal of Rheumatology. ,vol. 9, pp. 789- 793 ,(1982)
Tugwell P, Southwell D, Hart Le, Norman Gr, Buchanan Ww, Grace Em, Grading of tenderness as a source of interrater error in the Ritchie articular index. The Journal of Rheumatology. ,vol. 12, pp. 716- 717 ,(1985)
J. McEwen, S. P. McKenna, S. M. Hunt, Measuring health status: a new tool for clinicians and epidemiologists The Journal of the Royal College of General Practitioners. ,vol. 35, pp. 185- 188 ,(1985)
Jerry S.S. Lanchbury, Emma E.M. Jaeger, David M. Sansom, Margaret A. Hall, Paul Wordsworth, Judith Stedeford, John I. Bell, Gabriel S. Panayi, Strong primary selection for the Dw4 subtype of DR4 accounts for the HLA-DQw7 association with Felty's syndrome Human Immunology. ,vol. 32, pp. 56- 64 ,(1991) , 10.1016/0198-8859(91)90117-R
AA Drosos, JS Lanchbury, GS Panayi, HM Moutsopoulos, None, Rheumatoid arthritis in Greek and British patients. A comparative clinical, radiologic, and serologic study. Arthritis & Rheumatism. ,vol. 35, pp. 745- 748 ,(1992) , 10.1002/ART.1780350705
P. EMERY, H. BRADLEY, V. ARTHUR, E. TUNN, R. WARING, GENETIC FACTORS INFLUENCING THE OUTCOME OF EARLY ARTHRITIS-THE ROLE OF SULPHOXIDATION STATUS Rheumatology. ,vol. 31, pp. 449- 451 ,(1992) , 10.1093/RHEUMATOLOGY/31.7.449
J P Leigh, J F Fries, Predictors of disability in a longitudinal sample of patients with rheumatoid arthritis Annals of the Rheumatic Diseases. ,vol. 51, pp. 581- 587 ,(1992) , 10.1136/ARD.51.5.581