Water-Soluble NIR Absorbing and Emitting Indolizine Cyanine and Indolizine Squaraine Dyes for Biological Imaging.
作者： William E. Meador , Shane A. Autry , Riley N. Bessetti , Jacqueline N. Gayton , Alex S. Flynt
关键词: Indolizine 、 Indoline 、 Biological imaging 、 Water soluble 、 Sulfonate 、 Photochemistry 、 Chemistry 、 Cyanine 、 Absorption (electromagnetic radiation)
摘要: Organic dyes that absorb and emit in the near-infrared (NIR) region are potentially noninvasive, high-resolution, rapid biological imaging materials. Indolizine donor-based cyanine squaraine with water-solubilizing sulfonate groups were targeted this study due to strong absorptions emissions NIR region. As previously observed for nonwater-soluble derivatives, indolizine group retains a substantial shift toward longer wavelengths both absorption emission squaraines cyanines relative classically researched indoline donor analogues. Very high quantum yields (as much as 58%) have been >700 nm fetal bovine serum. Photostability studies, cell culture cytotoxicity, uptake specificity profiles all studied these dyes, demonstrating exceptional suitability.
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