Protective effect of Pycnogenol on cisplatin-induced ototoxicity in rats
作者： Aylin Eryilmaz , Nuket Eliyatkin , Buket Demirci , Yesim Basal , Imran Kurt Omurlu
DOI: 10.1080/13880209.2016.1177093
关键词: Cisplatin 、 French Maritime Pine Bark Extract 、 Oxidative stress 、 Ototoxicity 、 Pharmacology 、 Antioxidant 、 Single injection 、 Medicine
摘要: AbstractContext: Pycnogenol®, which is French maritime pine bark extract, a potent antioxidant. It used in medical conditions caused by oxidative stress. Cisplatin (cis-diamminedichloroplatinum II) an antineoplastic agent. However, its serious side effects such as ototoxicity limit usage.Objective: Antioxidants can be to prevent ototoxicity. We investigated the effect of Pycnogenol® on cisplatin-induced ototoxicity.Materials and methods: Rats were randomly assigned four groups five. Distortion product-evoked otoacoustic emissions (DPOAE) test was performed for each rat. The experimental follows: Control Group, Group: 10 mg/kg intraperitoneally 7 days, 15 mg/kg single injection cisplatin fifth day, Cisplatin + Pycnogenol® treatment additionally given. On eighth DPOAE was...
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