Novel functions of the Neurofibromatosis 2 tumour suppressor protein merlin

摘要: 9 REVIEW OF THE LITERATURE 11 1. CELL DIVISION CYCLE 2. CANCER GENES 12 2.1 Oncogenes 2.2 Tumour suppressor genes 13 3. ACTIN CYTOSKELETON 3.1 The actin cytoskeleton in disease 14 4. BAND 4.1 PROTEIN SUPERFAMILY ERM protein family 15 4.1.1 proteins 16 4.1.1.1 Structure of the 17 4.1.2 NF2 protein, merlin 4.1.3 Ezrin and neoplasia 19 4.1.3.1 Neurofibromatosis 2, 5. MOLECULAR INTERACTIONS AND FUNCTIONS MERLIN EZRIN 20 5.1 Association with 5.2 plasma membrane 22 5.3 Cell adhesion cell-cell communication 23 5.4 proliferation 24 6. REGULATION 26 6.1 Phosphorylation 6.2 RHO GTPases 29 6.3 Homotypic heterotypic binding 30 6.4 Other mechanisms regulation AIMS STUDY 32 METHODS 33 RESULTS DISCUSSION 34 HETEROTYPIC HOMOTYPIC (I) .......34 1.1 Heterotypic interactions 1.2 35 1.3 Merlin N-ERMAD C-ERMAD 36 1.4 Regulation dormant active states 37