Gene of the month: MET.
作者： Garret Skead , Dhirendra Govender
DOI: 10.1136/JCLINPATH-2015-203050
关键词: Hepatocyte growth factor 、 Hedgehog signaling pathway 、 Metastasis 、 Biology 、 Cancer 、 Cell growth 、 Gene duplication 、 Cancer research 、 Signal transduction 、 Bioinformatics 、 Cancer cell
摘要: The MET receptor tyrosine kinase and its ligand hepatocyte growth factor/scatter factor (HGF/SF) are potential therapeutic targets in many human malignancies, making this pathway an important focus of molecular cancer research. mutations have been detected various tumours. In addition, tumour types demonstrate HGF/SF overexpression amplification. signal transduction cascade is complex, manifests a broad spectrum mitogenic morphogenic functions, affecting cell proliferation, migration, differentiation, morphology survival. Cancer cells commandeer the physiological functions signalling axis to facilitate invasion metastasis. Significant progress has made development agents that inhibit MET-HGF/SF signalling. article, we outline key features gene, protein product HGF/SF, provide overview offer summary relevant pathological clinical directions
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