Multiple Metazoan Life-span Interventions Exhibit a Sex-specific Strehler–Mildvan Inverse Relationship Between Initial Mortality Rate and Age-dependent Mortality Rate Acceleration

摘要: The Gompertz equation describes survival in terms of initial mortality rate (parameter a), indicative health, and age-dependent acceleration b), aging. parameters were analyzed for several published studies. In Drosophila females, mating increases egg production decreases median life span, consistent with a trade-off between reproduction longevity. Mating increased parameter a, causing decreased whereas time b was decreased. inverse correlation indicates the Strehler-Mildvan (S-M) relationship, where loss low-vitality individuals yields cohort slower acceleration. steroid hormone antagonist mifepristone/RU486 reversed these effects. mifepristone showed robust S-M relationships across genotypes, dietary restriction relationship diets. Because nutrient optima differed females males, same manipulation caused opposite effects on rates versus males range concentrations. Similarly, p53 mutation mTOR mice span associated direction changes males. data demonstrate that genetic interventions have sex-specific sometimes sexually sexual antagonistic pleiotropy.