Endothelial dysfunction by acute hyperhomocyst(e)inaemia: restoration by folic acid.

摘要: Recent evidence demonstrates that hyperhomocyst(e)inaemia is a novel risk factor for cardiovascular diseases. In patients with chronic hyperhomocyst(e)inaemia, endothelial function impaired. However, whether per se cause or an epiphenomenon of dysfunction remains unknown. this study, we examined the effects methionine-induced acute on human function. healthy volunteers administered methionine (0.1 g/kg body weight, os), substrate homocyst(e)ine, without folic acid (20 mg, os) and flow-mediated vasodilatation brachial artery by high-resolution ultrasonography as non-invasive measure We also measured plasma levels homocyst(e)ine before 3, 8 24 h after loading. Methionine administration increased four times basal level at (P<0.0001, ANOVA). The returned to baseline h. Flow-mediated was significantly decreased half value ANOVA), whereas endothelium-independent glyceryl trinitrate not affected Co-administration did attenuate but completely prevented dysfunction. Our results suggest in humans methionine-rich diet may acutely impair function, which can be supplementation.