Potential of Methyl Fluoride as a Universal Reaction Gas to Overcome Spectral Interference in the Determination of Ultratrace Concentrations of Metals in Biofluids Using Inductively Coupled Plasma-Tandem Mass Spectrometry

摘要: Methyl fluoride (a mixture of 10% CH3F and 90% He) was evaluated as a reaction gas in inductively coupled plasma-tandem mass spectrometry (ICPMS/MS) the context determination ultratrace concentrations medically relevant metals (Al, Co, Cr, Mn, Ni, Ti, V) blood serum urine. Via product ion scanning, whereby only ions mass-to-charge ratio target nuclide were admitted into octopole cell, various formed for each elements identified at different flow rates. Limits detection (LODs) quantification (LOQs) linearity calibration curve documented under (i) optimized ICPMS/MS conditions single-element monitoring (ii) compromise conditions, allowing multielement determination. Even settings, instrumental LODs below 10 ng/L all elements, while use provided interference-free their biofluids interest. Quantitative data obtained Seronorm urine reference materials excellent agreement with corresponding values and/or results using double-focusing sector-field ICPMS (for those which no certified available or that affected during reconstitution), proving potential this analysis via ICPMS/MS.