Prognostic Factors in Patients With Metastatic Germ Cell Tumors Who Experienced Treatment Failure With Cisplatin-Based First-Line Chemotherapy

摘要: Purpose To develop a prognostic model in patients with germ cell tumors (GCT) who experience treatment failure cisplatin-based first-line chemotherapy. Patients and Methods Data from 1,984 GCT progressed after at least three cycles were treated conventional-dose or carboplatin-based high-dose salvage chemotherapy was retrospectively collected 38 centers/groups worldwide. One thousand five hundred ninety-four (80%) of eligible randomly divided into training set 1,067 (67%) validation 527 (33%). Seminomas aside for posthoc analyses. Primary end point the 2-year progression-free survival treatment. Results Overall, 990 (62%) relapsed 604 (38%) remained relapse free. Histology, primary tumor location, response, interval treatment, as well levels alpha fetoprotein, human chorionic gonadotrophin, presence liver, bone, brain metastases identified independent variables used to build set. Survival rates very similar. The estimated not included 75% low risk, 51% 40% intermediate 26% high only 6% high-risk patients. Due missing values individual variables, 69 could reliably be classified one these categories. Conclusion Prognostic are important experienced can construct guide strategies. J Clin Oncol 28:4906-4911. © 2010 by American Society Clinical Oncology