The influence of Trypanosoma brucei infection on local immunoglobulin responses of rats to Nippostrongylus brasiliensis
作者： H. Wedrychowicz , J.M. Maclean , P.H. Holmes
DOI: 10.1016/0020-7519(84)90025-0
关键词: Lung 、 Nematode 、 Antigen 、 Immunology 、 Parasitology 、 Biology 、 Trypanosoma brucei 、 Nippostrongylus brasiliensis 、 Antibody 、 Antibody Isotype 、 Microbiology
摘要: Abstract Wedrychowicz H. , Maclean J. M. and Holmes P. 1984. The influence of Trypanosoma brucei infection on local immunoglobulin responses rats to Nippostrongylus brasiliensis. International Journalfor Parasitology 14 : 453–458. Serum, intestinal lung antibody isotype brasiliensis were studied in normal trypanosome-infected Hooded Lister rats. Rats which received trypanosomes 7 days before N. had impaired serum IgG IgA. Bronchial mucosal was not reduced whilst IgA concentration these sites markedly diminished. Total M levels T. parasitised higher both sera sites. However, tests with radiolabelled adult nematode excretory-secretory antigens indicated that specific IgM reduced. Immunoglobulin A diminished most lungs also the intestine while antibodies decreased mucosae infected worm burdens than alone but expulsion delayed. results indicate as well systemic are trypanosome animals.
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