Nippostrongylus brasiliensis: systemic and local IgA and IgG immunoglobulin responses in parasitized rats.

摘要: Abstract Rats infected with the intestinal nematode Nippostrongylus brasiliensis expel adult worms between 12 and 16 days after infection, a phenomenon generally considered to involve antibodies. Samples of serum mucosa taken from rats at various times infection were examined for antibodies against N. using radioimmunoassay technique quantify in vitro parasite-binding capacity IgA IgG, as well their hemagglutinin precipitin titers. Total levels IgG also measured. It was found that there an almost 10-fold increase mucosal anti-worm during following whilst increased more gradually not so closely associated parasitic expulsion. Mucosal titers correlated changes IgA, reflected IgG. is close temporal relationship parasite binding worm expulsion provides useful indirect evidence local may be part effector mechanism.