METHODS AND COMPOSITIONS FOR ANTAGONIZING ANTI-APOPTOTIC Bcl-2-FAMILY PROTEINS
作者： Dayong Zhai , John C. Reed
DOI:
关键词: Bcl-2 family 、 Cytotoxic T cell 、 Cancer 、 Gambogic acid 、 Binding site 、 Cytotoxicity 、 Apoptosis 、 Biochemistry 、 Biology 、 Natural product
摘要: The cytotoxic natural product gambogic acid (GA) competes for BH3 peptide binding sites on several anti-apoptotic members of the Bcl-2 family proteins and neutralizes ability these to suppress release apoptogenic from isolated mitochondria. Structure-function analysis GA using analogs suggested a general correlation between competition cytoxicity activity. Compositions methods are provided its derivatives treating cancer discovering other compounds that useful through their interaction with Bcl-2-family proteins.
lens.org 参考文章(2)
Serguei Maliartchouk, Shailaja Kasibhatla, Nilantha Sudath Sirisoma, Ben Tseng, Han-Zhong Zhang, Jared Kuemmerle, Songchun Jiang, Nicole Marion English, Sui Xiong Cai, Katayoun Alavi Jessen, Methods of treating diseases responsive to induction of apoptosis and screening assays ,(2004)
Shailaja Kasibhatla, John Drewe, P. Reddy, Methods of identifying potentially therapeutically selective and effective anti-cancer agents that are inducers of apoptosis ,(2002)