Methods of treating diseases responsive to induction of apoptosis and screening assays
作者： Serguei Maliartchouk , Shailaja Kasibhatla , Nilantha Sudath Sirisoma , Ben Tseng , Han-Zhong Zhang
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摘要: The present invention pertains to a method of treating, preventing or ameliorating disease responsive induction the caspase cascade in an animal, comprising administering animal compound which binds specifically one more Apoptosis Inducing Proteins (AIPs). AIPs include Transferrin Receptor Related (TRRAIPs), Clathrin Heavy Chain (CHCRAIPs), IQ motif containing GTPase Activating Protein (IQGAPRAIPs), and Heat Shock (HSPRAIPs). also relates screening methods useful for drug discovery apoptosis inducing compounds. In particular, methodology using as target activators anticancer agents. can employ homogenous heterogenous binding assays purified partially AIPs; whole cell cells with altered levels AIPs. contemplates use gambogic acid GA-related compounds bind accordingly be used raise antibodies discovery. Alternatively, labeled GA is competitive Such afford high throughput chemical libraries activators.
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