Notch signaling and breast cancer.
作者： Michael Reedijk
DOI: 10.1007/978-1-4614-0899-4_18
关键词: Cell fate determination 、 Signal transduction 、 Cancer research 、 Breast cancer 、 Carcinogenesis 、 Notch signaling pathway 、 Biology 、 Oncogene 、 Mammary tumor 、 Stem cell
摘要: It has been more than two decades since Notch identified as an oncogene in mouse mammary tumor virus-infected mice. Since this discovery, activated signaling and up-regulation of tumor-promoting target genes have observed human breast cancer. In addition, high expression ligands receptors shown to correlate with poor outcome malignancy. affects multiple cellular processes including stem cell maintenance, fate specification, differentiation, proliferation, motility survival. Perturbation these activities is a hallmark carcinogenesis evidence continues accumulate that aberrant activity influences cancer progression through processes.
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