Asymmetric Michael additions of α-nitrocyclohexanone to aryl nitroalkenes catalyzed by natural amino acid-derived bifunctional thioureas.
作者： Manuel Jörres , Ingo Schiffers , Iuliana Atodiresei , Carsten Bolm
DOI: 10.1021/OL302005F
关键词: Catalysis 、 Amino acid 、 Thiourea 、 Bifunctional 、 Aryl 、 Organic chemistry 、 Chemistry
摘要: A series of new thiourea catalysts prepared from natural amino acids have been applied in organocatalytic asymmetric Michael additions α-nitrocyclohexanone to nitroalkenes. The resulting addition products are formed with excellent enantioselectivities (up an er 98:2) good yields 90%).
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