Organocatalytic asymmetric decarboxylative cyanomethylation of isatins using L-proline derived bifunctional thiourea.
作者： V. Pratap Reddy Gajulapalli , Poopathy Vinayagam , Venkitasamy Kesavan
DOI: 10.1039/C4OB00271G
关键词:
摘要: First asymmetric decarboxylative cyanomethylation of isatins is reported herewith using bifunctional thiourea derived from L-proline in good yields and enantioselectivities. This strategy enables the construction various 3-cyanomethylene substituted 3-hydroxyoxindoles enantioselective manner. Enantioselective synthesis CPC-1 alkaloid has been accomplished fewer steps.
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