Palladium Catalyzed Asymmetric Allylation of 3-OBoc-Oxindoles: An Efficient Synthesis of 3-Allyl-3-hydroxyoxindoles
作者： Samydurai Jayakumar , Nandarapu Kumarswamyreddy , Muthuraj Prakash , Venkitasamy Kesavan
DOI: 10.1021/ACS.ORGLETT.5B00034
关键词:
摘要: 3-Allyl-3-hydroxyoxindoles were synthesized in very good enantio- (up to 97% ee) and diastereoselectivities (dr up 7.6:1) with contiguous quaternary tertiary stereogenic centers by employing tartrate derived bi(oxazoline) Pd-catalyzed allylation of 3-OBoc-oxindole. Synthetic utility 3-allyl-3-hydroxyoxindole was demonstrated synthesizing a highly substituted spiro(oxindole-3,2′-tetrahydrofuran) derivative yield stereoselectivity.
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