A Leishmania-specific hypothetical protein expressed in both promastigote and amastigote stages of Leishmania infantum employed for the serodiagnosis of, and as a vaccine candidate against, visceral leishmaniasis.

作者： Vivian T Martins , Mariana C Duarte , Miguel A Chávez-Fumagalli , Daniel Menezes-Souza , Cecília SP Coelho

关键词: Leishmaniasis 、 Antigen 、 Leishmania 、 Parasitology 、 Amastigote 、 Biology 、 Leishmania infantum 、 Visceral leishmaniasis 、 Hypothetical protein 、 Virology

摘要: Background LiHyV is an antigenic hypothetical protein present in both promastigote and amastigote stages of Leishmania infantum, which was recently identified by immunoproteomic approach. A recombinant version this (rLiHyV) evaluated as a diagnostic marker for canine VL (CVL). In addition, the prophylactic efficacy rLiHyV protein, two its CD8+ T cell epitopes, has been analyzed murine model visceral leishmaniasis (VL).

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A Leishmania-specific hypothetical protein expressed in both promastigote and amastigote stages of Leishmania infantum employed for the serodiagnosis of, and as a vaccine candidate against, visceral leishmaniasis.

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A Leishmania-specific hypothetical protein expressed in both promastigote and amastigote stages of Leishmania infantum employed for the serodiagnosis of, and as a vaccine candidate against, visceral leishmaniasis.

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